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909 bioactive compounds library  (Iconix Pharmaceuticals Inc)
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Iconix Pharmaceuticals Inc 909 bioactive compounds library
HCS-based assays employed in trypanosomatid drug discovery
909 Bioactive Compounds Library, supplied by Iconix Pharmaceuticals Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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HCS-based assays employed in trypanosomatid drug discovery

Journal: Memórias do Instituto Oswaldo Cruz

Article Title: Past and future of trypanosomatids high-throughput phenotypic screening

doi: 10.1590/0074-02760210402

Figure Lengend Snippet: HCS-based assays employed in trypanosomatid drug discovery

Article Snippet: , L. donovani , Laboratory strain: MHOM/SD/62/1S-cl2D , Intracellular amastigotes , None , Human acute monocytic leukemia (THP-1) cells , Number of host cells (cytotoxicity evaluation) and number of amastigotes per cell , Parasites kDNA and cell nucleus detected by DAPI. Cell boundary was delineated around the nucleus object. , 909 bioactive compounds library from Iconix Biosciences , Primary screening and cytotoxicity evaluation performed in the same assay. A similar method was used to generate the dose-response curves , (96).

Techniques: Infection, Immunostaining, Cytotoxicity Assay, Activity Assay, Luciferase, Proliferation Assay, Imaging, Time-Kill Assay, Derivative Assay, Expressing, Drug discovery, Staining, Labeling, SYBR Green Assay